Comment 37 for bug 1934221

My system is focal. Can't try Hirsute yet, dont have any systems with such error appearing.

It doesnt work at all for me, fail to resolve anything

Link 2 (enp3s0)
      Current Scopes: DNS
DefaultRoute setting: yes
       LLMNR setting: yes
MulticastDNS setting: no
  DNSOverTLS setting: no
      DNSSEC setting: no
    DNSSEC supported: no
  Current DNS Server: 2a0d:e40:0:4000::1
         DNS Servers: 2a0d:e40:0:4000::1
                      fd2c:bf12:1194::1
                      10.255.255.1
                      8.8.8.8
          DNS Domain: ~.
                      spinesystems.solutions

udp 0 0 127.0.0.53:53 0.0.0.0:* 4106635/systemd-res
resolv.conf nameserver: nameserver 127.0.0.53

dig @127.0.0.53

; <<>> DiG 9.16.1-Ubuntu <<>> @127.0.0.53
; (1 server found)
;; global options: +cmd
;; Got answer:
;; ->>HEADER<<- opcode: QUERY, status: SERVFAIL, id: 4404
;; flags: qr rd ra; QUERY: 1, ANSWER: 0, AUTHORITY: 0, ADDITIONAL: 1

;; OPT PSEUDOSECTION:
; EDNS: version: 0, flags:; udp: 65494
;; QUESTION SECTION:
;. IN NS

;; Query time: 0 msec
;; SERVER: 127.0.0.53#53(127.0.0.53)
;; WHEN: Mon Oct 04 12:34:50 EEST 2021
;; MSG SIZE rcvd: 28

dig +short @2a0d:e40:0:4000::1 www.google.com
142.250.200.196

# systemd-resolve -4 www.google.com
www.google.com: resolve call failed: No appropriate name servers or networks for name found

But didnt rebooted yet after fetching new systemd.